Background:

The prevalence of Parkinson’s disease (PD) increases as the population ages. Studies have shown that some cardiometabolic comorbidities could be associated with risk or protection against developing PD. A retrospective case-control study was carried out to analyze the relationship between PD and cardiometabolic comorbidities.

Material and methods:

Subjects with PD and controls without PD were consecutively recruited. Data on type 2 diabetes mellitus, systemic arterial hypertension (SAH), dyslipidemia and body mass index were collected. Logistic regression analyses were carried out.

Results:

A total of 781 subjects with PD (56.5% male) and 1,000 controls (44.4% males) were included. After adjusting for age and gender, SAH was found as an independent risk factor (OR 1.32, CI 95% 1.05-1.67, p=0.02), and obesity a protective factor (OR 0.72, CI 95% 0.56-0.93, p=0.01).

Conclusion:

Subjects with SAH had an higher risk of having PD. while obese subjects had a lower risk of having PD. The relationship between cardiometabolic disease, its treatment, and PD etiopathogenesis appears to be extremely complex given the amount of contradictory data.