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Gaceta médica de México
versión On-line ISSN 2696-1288versión impresa ISSN 0016-3813
Resumen
MARTINEZ-GARCIA, Geovedy et al. Triglycerides-glucose index impact on in-hospital mortality in acute myocardial infarction. Results from the RECUIMA multicenter registry. Gac. Méd. Méx [online]. 2022, vol.158, n.2, pp.86-92. Epub 16-Mayo-2022. ISSN 2696-1288. https://doi.org/10.24875/gmm.21000628.
Introduction:
The triglycerides-glucose (TyG) index is considered a new marker of insulin resistance, and is associated with the development of cardiovascular diseases.
Objective:
To evaluate the capability of TyG index to predict in-hospital mortality in patients with acute ST-elevation myocardial infarction.
Methods:
Multicenter cohort study that enrolled 1123 patients included in the Cuban Registry of Acute Myocardial Infarction between January 2018 and June 2021.
Results:
TyG index optimal cutoff point to predict mortality was 8.96 (sensitivity, 65.2%; specificity, 62.0%; area under the curve; 0.636; p < 0.001). In-hospital mortality was significantly higher in the group with TyG index ≥ 8.96. The logistic regression analysis revealed that the TyG index was an independent mortality predictor (OR = 2.959; 95% CI = 1.457-6.010; p = 0.003). When the TyG index was included in the multivariate model, it increased its predictive capacity (area under the curve, 0.917, p < 0.001). Kaplan-Meier curves showed significant differences between patient groups (p < 0.001).
Conclusions:
The TyG index constitutes an independent risk factor of in-hospital mortality in patients with acute ST-elevation myocardial infarction.
Palabras llave : Triglycerides-glucose index; Acute myocardial infarction; Mortality; Glycemia; Triglycerides; Insulin resistance.