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Gaceta médica de México
versión On-line ISSN 2696-1288versión impresa ISSN 0016-3813
Resumen
TELLEZ-ROJO, Martha M.; BAUTISTA-ARREDONDO, Luis F.; ROSA-PARRA, Antonio y MARTINEZ SILVA, Gisela. Prenatal exposure to metals and concentration thereof in umbilical cord blood in a Mexico City cohort. Gac. Méd. Méx [online]. 2023, vol.159, n.2, pp.132-137. Epub 24-Abr-2023. ISSN 2696-1288. https://doi.org/10.24875/gmm.22000329.
Background:
In Mexico, there is a paucity of evidence on the magnitude of prenatal exposure to metals.
Objective:
To estimate the concentration of arsenic, cadmium, manganese and lead in umbilical cord blood (UCB) and its association with maternal blood concentrations during pregnancy and delivery.
Material and methods:
Metal concentration in maternal blood was analyzed during pregnancy (n = 901), delivery (n = 732) and in UCB (n = 512) from participants of the PROGRESS cohort residing in Mexico City. The association between concentrations in UCB and maternal biomarkers was analyzed using generalized linear models, adjusted for relevant covariates.
Results:
Mean concentrations (μg/L) of lead, arsenic and manganese in UCB were 27.14 (25.28-29.14), 0.77 (0.71-0.84) and 42.60 (40.45-44.83), respectively. Cadmium concentration could not be estimated because 86.2% of measurements were below the detection limit. Lead and manganese concentrations in UCB were significantly associated with maternal biomarkers during pregnancy and delivery; at delivery, association was only observed with arsenic.
Conclusions:
Prenatal exposure to toxic metals in sensitive periods of organogenesis shows a neglected public health problem. Biomonitoring of the population and establishment of regulations aimed at providing care to vulnerable populations is required.
Palabras llave : Biomonitoring; Umbilical cord; Pregnancy; Prenatal exposure; Metals; Blood.