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Gaceta médica de México
versión On-line ISSN 2696-1288versión impresa ISSN 0016-3813
Resumen
REMES-TROCHE, José M. et al. Celiac disease seroprevalence in patients with infertility. A case-control study. Gac. Méd. Méx [online]. 2023, vol.159, n.2, pp.145-149. Epub 24-Abr-2023. ISSN 2696-1288. https://doi.org/10.24875/gmm.22000360.
Background:
Although most patients with celiac disease (CD) have digestive manifestations, in some of them they may be of extraintestinal (atypical) nature, such as chronic anemia, ataxia, and fertility disorders.
Objective:
To determine the prevalence of CD-related antibodies in Mexican women with fertility disorders.
Material and methods:
Case-control study of women who attended evaluation for fertility disorders in a specialized center. h-tTG-IgA, gliadin IgA II and gliadin IgG II were quantified; titers > 30 IU were considered positive.
Results:
One-hundred and seventy-one cases and 171 controls were included; 137 patients (80.1%) had infertility, and 34 (19.9%), sterility. Eight patients (4.6%, 95% CI = 2.3-8.9) had at least one positive marker for CD in comparison with one woman in the control group (0.5%, 95% CI = 0.01-3, p = 0.04, odds ratio = 8.3). Six of the eight patients had unexplained infertility.
Conclusions:
Up to 4.6% of women with infertility had at least one positive marker for CD. As in other parts of the world, screening for CD could be recommended in women with infertility, especially in those with unexplained infertility.
Palabras llave : Celiac disease; Infertility; Enteropathy; Sterility; Mexico.