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Gaceta médica de México
versión On-line ISSN 2696-1288versión impresa ISSN 0016-3813
Resumen
CASTRO-MACIAS, Jaime I.; RODRIGUEZ-JIMENEZ, José C. y MENA-NOVOA, Andrés. Rituximab in the treatment of multiple sclerosis. Experience of a tertiary care hospital in Mexico. Gac. Méd. Méx [online]. 2023, vol.159, n.3, pp.184-189. Epub 12-Jun-2023. ISSN 2696-1288. https://doi.org/10.24875/gmm.23000014.
Background:
Multiple sclerosis is a chronic, autoimmune, degenerative disease. Therapies targeting B-cells have been shown to be effective in its treatment; however, there are few studies evaluating their efficacy in the Mexican population.
Objective:
To evaluate the clinical impact of rituximab in patients with newly-diagnosed relapsing-remitting multiple sclerosis (RRMS).
Material and methods:
Real life, descriptive study, in which rituximab was evaluated as treatment for RRMS over a 24-month period. Pre- and post-treatment clinical variables were analyzed; a comparison was made between treatment-naïve and non-treatment-naïve patients.
Results:
Twenty-eight patients with RRMS were included. Mean age at diagnosis was 30.7 years, and 22 patients were treatment-naïve (78.5 %). After 24 months, there was a mean reduction of 1.8 points in the EDSS scale and a decrease in the number of active lesions on magnetic resonance imaging; a significant difference in both variables could be established (p < 0.05). However, the logistic regression model did not show a relationship between the variables for achieving NEDA-3 criteria. No serious adverse events were observed.
Conclusions:
Treatment with rituximab resulted in significant clinical and radiological improvement in treatment-naïve and non-treatment-naïve Mexican patients with RRMS.
Palabras llave : Disability; Multiple sclerosis; Relapsing-remitting; Rituximab.