Resumen

MEDINA RIOJA, Raúl et al. Devic's disease. A case report and literature review. Rev. Fac. Med. (Méx.) [online]. 2018, vol.61, n.1, pp.26-32. ISSN 2448-4865.

Optic neuromyelitis or Devic’s disease is a rare inflammatory disease of the central nervous system (CNS) that predominantly affects the optic nerve and spinal cord. The mechanism of the disease is given by the production of IgG antibodies whose main target is the acuaporine channel 4 (AQP4) that trigger an inflammatory and demyelinating process in the aforementioned structures. We present the case of a patient who developed chronic and fluctuating sensitive episodes with visual impairment, without improvement after conventional treatment. During the diagnostic approach we found demyelinating lesions and positive AQP4-antibodies, this lead to a diagnosis of optic neuromyelitis. A positive response was obtained to the therapy with monoclonal antibodies.

Palabras llave : optic neuritis; demyelinating myelitis.