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Revista de investigación clínica
versión On-line ISSN 2564-8896versión impresa ISSN 0034-8376
Resumen
MARQUEZ, Manlio F. et al. Polymorphisms in B-Adrenergic Receptors Are Associated with Increased Risk to Have a Positive Head-Up Tilt Table Test in Patients with Vasovagal Syncope. Rev. invest. clín. [online]. 2019, vol.71, n.2, pp.124-132. Epub 12-Abr-2021. ISSN 2564-8896. https://doi.org/10.24875/ric.18002734.
Background
Vasovagal syncope (VVS) is a frequent clinical condition in which a genetic background seems to be implicated. Considering that the adrenergic receptors (ARs) may play a role in VVS, the present study has as principal aim to determine if the α- and β-AR (ADRA and ADRB) gene polymorphisms are associated with an increased risk to have a positive head-up tilt table (HUTT) test in patients with VVS. Methods: Nine polymorphisms in the ADRA1A (rs1048101, rs1383914, rs574584, and rs573542), ADRB1 (rs1801252 and rs1801253), ADRB2 (rs1042713 and rs1042714), and ADRB3 (rs4994) genes were analyzed using the 5 exonuclease TaqMan genotyping assay in a group of 134 patients with VVS.
Results
Under different models, the rs1801252 (OR = 8.63, 95% CI: 0.95-78.72, Precessive = 0.02), rs1042713 (OR = 1.94, 95% CI: 1.02-3.66, Padditive = 0.04), and rs4994 (OR = 2.46, 95% CI: 1.01-6.01, Pdominant = 0.042 and OR = 2.62, 95% CI: 1.04-6.63, Pover-dominant = 0.03) polymorphisms were associated with increased risk for a positive HUTT. All models were adjusted for statistically significant covariates.
Conclusion
These results suggest that some polymorphisms of the β-AR genes could contribute to a positive tilt test in patients with VVS.
Palabras llave : Adrenergic receptors; Genetics; Head-up tilt testing; Polymorphism; Vasovagal syncope.