Resumen

RODRIGUEZ, Augusto et al. Effects of the application of anti-rabies vaccine in dogs that were vaccinated during the massive antirabies vaccination campaign in Lima-Peru in 1993. Nova scientia [online]. 2011, vol.3, n.6, pp.32-46. ISSN 2007-0705.

In this work we determined the immune response after anti-rabies vaccination campaigns massive in 19 districts of the Lima city. The method used was the titration of anti-rabies antibodies by serum neutralization test in mice, a technique that was applied to a significant sample of blood serum of the canine population vaccinated. It took 54 random samples of dogs' teething rings that joined the Center for Anti-rabies of Lima to be clinically observed for a period of 10 days. Of the 54 serum samples that were tested, 28 (52%) were positive (titres of 0.5-8.39 IU/ml), whereas 26 (48%) remaining samples gave titres below 0.5 IU/ml and others were negative to the test. The age group of the largest sampling counted to population of dogs most risk (1-3 years old). In this age group, 14 dogs (26%) had sera with protection, whereas 18 dogs (33%) the test was negative. With regard to sex, the group of male dogs (considered higher risk) had a greater number of individuals (44 dogs) with respect to the group of females (10 dogs) and only 24 male dogs (45%) gave evidence of protection anti-rabies. In conclusion, we can say that 52% of dogs vaccinated during the previous massive campaigns of vaccination against rabies in Lima in 1993, had protective antibody titers against rabies virus.

Palabras llave : serum neutralization; antibody titres; anti-rabies vaccination; anti-rabies protection.