Resumen

MEJIA-NEPOMUCENO, Fidencio; MARTINEZ-MALDONADO, Fernando; PEREZ-PADILLA, Rogelio  y  VAZQUEZ-PEREZ, Joel Armando. Determinants of pathogenicity in pandemic influenza virus in Mexico: viral factors associated with severity. Neumol. cir. torax [online]. 2018, vol.77, n.4, pp.297-304. ISSN 0028-3746.

The influenza virus often causes seasonal infections and occasionally pandemics which increase the level morbidity and mortality of respiratory diseases in humans. The influenza virus is capable of adapting to several hosts while circulating in a normal and constant manner in aquatic birds, poultry, pigs, horses and humans. Interaction between different viral subtypes in these hosts can generate new variants. In addition, point mutations naturally occur in all genes of the virus, which may confer advantages to viral replication, adaptation and evasion of the immune system, and allow viral isolates the probability of being more pathogenic. Characterization of the determinants of pathogenicity, allow monitoring and detecting possible strains at an early stage that may pose a threat to the human population. This will also contribute to identify possible molecular changes in the influenza virus genome, and to correlate these changes to the virulence and pathogenicity of the virus.

Palabras llave : Determinants of pathogenicity; influenza A H1N1pdm09; characterization.