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Revista mexicana de pediatría
versión impresa ISSN 0035-0052
Resumen
MARQUEZ-SAINZ, Norma Alejandra et al. Factors related to the honeymoon period in pediatric patients with type 1 diabetes mellitus during the first year of diagnosis. Rev. mex. pediatr. [online]. 2022, vol.89, n.5, pp.184-189. Epub 01-Dic-2023. ISSN 0035-0052. https://doi.org/10.35366/110503.
Introduction:
in type 1 diabetes mellitus (DM1) there is autoimmune destruction of pancreatic β cells with metabolic decompensation. In the first months of starting treatment, a period of partial remission or “honeymoon” may appear, in which there is a decrease in exogenous insulin requirements.
Objective:
to identify factors associated with partial remission in pediatric patients with DM1, during the first 12 months after diagnosis.
Material and methods:
retrospective study of a cohort of pediatric patients initially diagnosed with DM1, in a private hospital in Mexico City. We analyzed the clinical characteristics at diagnosis, subsequent management, and the stay in partial remission during the first 12 months after diagnosis.
Results:
forty-four patients with a median age of nine years were included, 25 were male (56.8%). 70.5% (31/44) presented partial remission at some point during follow-up, but for 12 months only 22 (50%) maintained partial remission. Factors associated with losing partial remission at 12 months were: age less than six years (OR: 6.9, 95% CI 1.06-44.9) and do not perform continuous blood glucose monitoring (OR = 6.7, 95% CI 1.3-34.4).
Conclusion:
during the first year of treatment, up to 70% of patients with a recent diagnosis of DM1 may have partial remission. Better blood glucose monitoring and being a patient older than six years are associated with partial remission.
Palabras llave : honeymoon; diabetes mellitus type 1; continuous glucose monitoring; risk factors; children; adolescents.