Resumen

BUSTO-RUANO, José Pablo et al. Moderately differentiated neuroendocrine carcinoma of the nasal cavity, a case report and literature review. Rev. sanid. mil. [online]. 2021, vol.75, n.2, e03.  Epub 29-Sep-2023. ISSN 0301-696X.  https://doi.org/10.56443/rsm.v75i2.223.

Neuroendocrine carcinomas are rare tumors of the nose and sinuses. They are considered primitive tumors and are the least differentiated from the diffuse neuroendocrine system.

We report a 49-year-old female patient who attends the otolaryngology service at the Central Military Hospital referring mass in the left nasal cavity with a progressive growth over a period of 9 months, including epistaxis, as well as left nasal obstruction. Magnetic Resonance Imaging and Computed Tomography imaging studies showed a tumor occupying the entirety of the left nasal cavity to the nasopharynx, with heterogeneous uptake of the contrast medium. Tumor resection is decided by endoscopic approach (maxillary sinusotomy type III, left anterior and posterior ethmoidectomy, left sphenoid Draf type II, left frontal Draf IIa as well as posterior septectomy). The pathology service reported a moderately differentiated neuroendocrine carcinoma. The treatment was decided joint session with the medical oncology service.

These types of tumors are a diagnostic challenge because of the complexity to differentiate them in a histopathological study. Their effective differentiation can have a clinical impact, that’s why the advances in therapeutic intervention could prolong patient survival, improve quality of life and even find a cure.

Palabras llave : Neuroendocrine carcinoma; sinonasal neuroendocrine neoplasm; sinonasal malignant tumors; sinuses; nasal cavity.