Resumen

ALGOHARY, Ayman. M.; HASSAN, Mohamed M.; ALMALKI, Sami G.  y  AL-MALKI, Esam S.. Design, Synthesis, and Evaluation of New Colorimetric Chemosensors Containing Quinazolinones Moiety for some Cations Detection in an Aqueous Medium and Biological Sample. J. Mex. Chem. Soc [online]. 2021, vol.65, n.3, pp.331-346.  Epub 14-Feb-2022. ISSN 1870-249X.  https://doi.org/10.29356/jmcs.v65i3.1500.

The current project deals with designing and synthesizing of colorimetric chemosensors to detect the cations in the aqueous medium and biological sample. To achieve this goal a new series of quinazolinone derivatives were synthesized via reaction of the novel 6-nitro-2-propyl-4H- benzo[d][1,3]oxazin-4-one (3) with selected nitrogen nucleophiles, namely, formamide, hydrazine hydrate, hydroxylamine hydrochloride, O-phenylendiamine, O-aminophenol and O-aminothiophenol, urea and/or thiourea. Structures of the new compounds have been investigated depending on their spectral data (IR, 1H NMR, 13C NMR and MS) and elemental analyses. Some of the newly synthesized products exhibited a significant response as chemosensors for some cations detection. The synthesized chemosensors 11a and 11b showed high-selectivity and specificity towards cooper (CuII) and mercury (HgII) cations detection through exhibiting colormetric responses. Chemosensors 7 and 10 b showed high selectivity toward cadmium (CdII) cation, whilst other examined compounds (9b, c, 10a, 12, 13, and 14) did not exhibit colorimetric response in all cation's samples.

Palabras llave : Chemosensor; quinazolinone; copper; cadmium; mercury.

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