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Revista alergia México
versión On-line ISSN 2448-9190
Resumen
CORTES-GUZMAN, José Santiago; VELOZA, Karen T.; DOMINGUEZ, Juan D. y PINZON-TOVAR, Alejandro. Leukocytoclastic vasculitis as an adverse effect of propylthiouracil. A case report. Rev. alerg. Méx. [online]. 2023, vol.70, n.1, pp.51-54. Epub 25-Ago-2023. ISSN 2448-9190. https://doi.org/10.29262/ram.v70i1.1210.
Background:
The most common cause of hyperthyroidism is Graves' disease. Propylthiouracil (PTU) is one of the drugs used to treat this disease. Leukocytoclastic vasculitis is described among dermatologic adverse effects of PTU.
Case report:
A 18-year-old woman, allergic to methimazole, developed a vasculitis associated to ANCAs with characteristics of leukocytoclastic vasculitis, associated to PTU treatment. She did not present systemic involvement. PTU treatment was suspended. Two months later, the skin lesions had almost completely resolved.
Conclusions:
Leukocytoclastic vasculitis should be considered in the spectrum of complications caused by the consumption of propylthiouracil. The lesions can manifest over time, from a few weeks to years after taking the drug. When there is no systemic involvement, propylthiouracil suspension is sufficient to cure the disease.
Palabras llave : Hyperthyroidism; Graves disease; Propylthiouracil; Vasculitis associated with anti-neutrophil cytoplasm antibodies; Leukocytoclastic vasculitis.
