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Acta pediátrica de México
versión On-line ISSN 2395-8235versión impresa ISSN 0186-2391
Resumen
RIOS-MORENO, MP et al. Risk factors associated with the metabolic bone disease of prematurity in neonatal intensive care unit of reference. Acta pediatr. Méx [online]. 2016, vol.37, n.2, pp.69-78. ISSN 2395-8235.
INTRODUCTION:
Metabolic bone disease of prematurity (MBD) results from bone demineralization. There are factors that must be monitored in order to early diagnosis and treatment.
AIM:
This study was conducted to determine risk factors associated with the metabolic bone disease of prematurity.
METHOD:
A Cross-sectional study was conducted in October/2011 to October/2012. We included 120 preterm infants with gestational age <37 weeks, birth weight ≤ 1500 grams and postnatal age ≥ 21 days. Diagnosis: hypophosphatemia (< 3.5 mg/dL), normocalcemia (8.5-10 mg/ dL) or hypocalcemia (< 8.5 mg/dL) increase in alkaline phosphatase (> 900 IU/L). We calculated odds ratio (OR). Data were analysed by Student t-test and the chi-square test.
RESULTS:
Metabolic bone disease of prematurity was diagnosed in 58 (48%) patients, weight 1067 ± 216 grams, gestational age 28 ± 1.6 weeks, postnatal age 41 ± 15.5 days. Gender male 32 (55%). The risk factors associated with the disease were: birth weight ≤ 1,000 grams OR 4.64 (2.13-10.10), moderate or severe bronchopulmonary dysplasia 3.13 (1.44-6.81), sepsis events ≥ three OR 3.43 (1.62-7.28), prolonged sedation OR 4.09 (1.06-15.73), prolonged corticoid OR 9.54 (2.06-44.16).
CONCLUSIONS:
Is probably the birth weight less than 1,000 grams, moderate or severe bronchopulmonary dysplasia, three or more events of sepsis and prolonged sedation and corticoid were significant risk factors for MBD.
Palabras llave : Risk factors; bone disease; prematurity.