SciELO - Scientific Electronic Library Online

 
vol.64 número1Noninvasive Determination of the Amount of Ethanol in Liquid Mixtures by Ultrasound Using Bilinear Interpolation Method índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

Links relacionados

  • No hay artículos similaresSimilares en SciELO

Compartir


Journal of the Mexican Chemical Society

versión impresa ISSN 1870-249X

Resumen

NIBIN JOY, Muthipeedika; BODKE, Yadav D.; TELKAR, Sandeep  y  BAKULEV, Vasiliy A.. Synthesis of Coumarins Linked With 1,2,3-Triazoles under Microwave Irradiation and Evaluation of their Antimicrobial and Antioxidant Activity. J. Mex. Chem. Soc [online]. 2020, vol.64, n.1, pp.53-73.  Epub 31-Dic-2020. ISSN 1870-249X.  https://doi.org/10.29356/jmcs.v64i1.1116.

A series of coumarin derivatives linked with 1,2,3-triazoles has been synthesized by utilizing the copper catalyzed azide-alkyne cycloaddition reaction and were screened for their antimicrobial and antioxidant properties. Some of the compounds displayed promising antibacterial activities (MIC ranging from 5-150 µg/mL) and moderate antifungal activities as compared to the respective standards. The compounds 4k and 4g displayed good antibacterial activity when compared with the standard, Ciprofloxacin, and 4n exhibited better antifungal activity when compared to other synthesized compounds. The in silico docking studies of the active compounds were carried out against the gyrase enzyme and from those studies, it was acknowledged that 4k possessed significant hydrogen bonding and hydrophobic interactions which could be the plausible reason for its superior activity as compared to the other synthesized compounds. The compounds 4h and 4q showed promising antioxidant activity when compared with the standard, BHT, which could be attributed to the presence of electron donating substituents.

Palabras llave : Coumarin; 1,2,3-triazole; click chemistry; antimicrobial; antioxidant.

        · resumen en Español     · texto en Inglés