Resumen

GALICIA-NEGRETE, Gustavo  y  FALFAN-VALENCIA, Ramcés. Mediators of inflammatory response in asthma and its association with obesity. Rev. alerg. Méx. [online]. 2017, vol.64, n.2, pp.198-205. ISSN 2448-9190.  https://doi.org/10.29262/ram.v64i2.259.

There is an increase in the prevalence of asthma and obesity, constituting a public health problem at national and global levels. The association between the two pathologies has not been clearly determined; however, a certain synergy has been proposed, which leads to more severe bronchospasms, longer recovery time, and more prolonged use of medications in obese asthmatic patients. The discovery of leptin, an adipokine that is directly related to the amount of total body fat and the production of proinflammatory cytokines, has generated greater interest in white adipose tissue. Our objective was to describe the possible mechanisms involved and the association between obesity and asthma. A bibliographic search was conducted in the scientific literature using the National Biotechnology Information Center (NCBI) database of the USA as a search tool; keywords used were: asthma, leptin, obesity and inflammation. There are numerous clinical and experimental studies that explore the role of obesity as an inflammatory entity in asthma, some of which have evaluated the role of “shared” genetic polymorphisms in both pathologies. Apparently, the interaction between asthma and obesity is complex, there are mechanisms that link both pathologies, these can influence the improvement or exacerbation of symptoms.

Palabras llave : Asthma; Inflammation; Leptin; Obesity.