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Gaceta médica de México
versão On-line ISSN 2696-1288versão impressa ISSN 0016-3813
Resumo
HERNANDEZ-SOLIS, Alejandro et al. Identification of Mycobacterium bovis in patients diagnosed with pulmonary and extrapulmonary tuberculosis. Gac. Méd. Méx [online]. 2019, vol.155, n.6, pp.608-612. Epub 25-Out-2021. ISSN 2696-1288. https://doi.org/10.24875/gmm.19005407.
Introduction:
In Mexico, there is an alarming increase in the number of cases of Mycobacterium bovis infection on pulmonary and extrapulmonary presentations. The lack of timely identification triggers complications and increases mortality.
Objective:
To know the frequency of M. bovis infections in clinical samples of patients with tuberculosis in the mycobacteria laboratory of a reference hospital in Mexico City.
Method:
Prospective, descriptive study. Strains isolated from biological material were studied in Löwestein-Jensen and MGITI960 cultures. M. bovis was identified by amplifying the RD9 fragment with end-point polymerase chain reaction (PCR).
Results:
Eight-hundred and fifty tuberculosis-diagnosed patients were included; in 441 cases, Mycobacterium tuberculosis was confirmed by positive culture (250 pulmonary, 65 ganglionic, 39 renal, 34 meningeal, 25 miliary, 14 pleural, 8 peritoneal, 4 bone and 2 pericardial cases). Forty-eight strains (10.8%) were typified as M. bovis by amplification of the RD9 fragment with end-point PCR.
Conclusions:
M. bovis is not currently thought of a causative agent of tuberculosis, which could be the cause of pharmacological treatment failure. In this study, the main extrapulmonary form was observed to be cervical lymphadenopathy.
Palavras-chave : Tuberculosis; Mycobacterium bovis; End-point polymerase chain reaction.