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Gaceta médica de México
versão On-line ISSN 2696-1288versão impressa ISSN 0016-3813
Resumo
TOLEDO-SALINAS, Otoniel; SANCHEZ-HURTADO, Luis A. e RODRIGUEZ-SILVERIO, Juan. Association of fever and antipyretic treatment with progressive organ dysfunction in sepsis: Prospective cohort. Gac. Méd. Méx [online]. 2021, vol.157, n.4, pp.391-397. Epub 13-Dez-2021. ISSN 2696-1288. https://doi.org/10.24875/gmm.20000756.
Introduction:
Whether fever and antipyretic treatment are related to progression of organ dysfunction (POD) in sepsis is not known.
Objective:
To evaluate the association of fever and antipyretic treatment with POD in sepsis.
Methods:
Prospective cohort study of patients with sepsis. Maximum axillary temperature (T° Max), antipyretic drugs total dose and daily SOFA score were recorded. POD was defined as an increase ≥ 1 point on the SOFA score. A multivariate logistic regression model was used to evaluate the studied association.
Results:
305 patients were included: 163 were women (53.4 %), with a SOFA score of 8 points (6-11); 130 participants (42.62 %) had T° Max ≥ 38 °C, and 76 (24.9 %), POD. Mortality in patients with fever was 26.2 % vs. 20 % (p = 0.21), and with POD, 73.7 % vs. 5.7 % (p = 0.01). T° Max ≥ 39 °C had an OR of 4.96 (95 % CI = 1.97-12.47, p = 0.01); and the use of antipyretics, an OR of 1.04 (95 % CI: 0.58-1.86, p = 0.88).
Conclusions:
An axillary T° Max ≥ 39 °C is a risk factor for POD in sepsis. The use of antipyretics was not associated with POD.
Palavras-chave : Fever; Antipyretic; Sepsis; Organ dysfunction.