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Gaceta médica de México
versão On-line ISSN 2696-1288versão impressa ISSN 0016-3813
Resumo
CERVANTES-ARRIAGA, Amin et al. Association between cardiometabolic comorbidities and Parkinson’s disease in a Mexican population. Gac. Méd. Méx [online]. 2021, vol.157, n.6, pp.645-650. Epub 13-Dez-2021. ISSN 2696-1288. https://doi.org/10.24875/gmm.21000294.
Background:
The prevalence of Parkinson’s disease (PD) increases as the population ages. Studies have shown that some cardiometabolic comorbidities could be associated with risk or protection against developing PD. A retrospective case-control study was carried out to analyze the relationship between PD and cardiometabolic comorbidities.
Material and methods:
Subjects with PD and controls without PD were consecutively recruited. Data on type 2 diabetes mellitus, systemic arterial hypertension (SAH), dyslipidemia and body mass index were collected. Logistic regression analyses were carried out.
Results:
A total of 781 subjects with PD (56.5% male) and 1,000 controls (44.4% males) were included. After adjusting for age and gender, SAH was found as an independent risk factor (OR 1.32, CI 95% 1.05-1.67, p=0.02), and obesity a protective factor (OR 0.72, CI 95% 0.56-0.93, p=0.01).
Conclusion:
Subjects with SAH had an higher risk of having PD. while obese subjects had a lower risk of having PD. The relationship between cardiometabolic disease, its treatment, and PD etiopathogenesis appears to be extremely complex given the amount of contradictory data.
Palavras-chave : Body mass index; Diabetes mellitus; Dyslipidemia; Hypertension; Parkinson’s disease; Risk.