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Gaceta médica de México
versão On-line ISSN 2696-1288versão impressa ISSN 0016-3813
Resumo
MARTINEZ-RODRIGUEZ, Erick J. et al. Evaluation of the usefulness of vitamin D as a predictor of mortality in patients with COVID-19. Gac. Méd. Méx [online]. 2022, vol.158, n.1, pp.32-37. Epub 25-Abr-2022. ISSN 2696-1288. https://doi.org/10.24875/gmm.21000390.
Introduction:
One of the functions of vitamin D is to regulate respiratory epithelium inflammatory response; therefore, deficiency of this vitamin in the context of COVID-19 could constitute a predictive biomarker of the disease outcome.
Objective:
To evaluate the usefulness of vitamin D for predicting mortality in patients with COVID-19.
Methods:
Observational, retrospective study in which 154 patients diagnosed with COVID-19 were included, out of whom 111 survived and 43 died. Vitamin D concentration was determined in all of them.
Results:
A log-rank p-value < 0.032 was obtained for survival when vitamin D concentration was used as a categorical variable (≤ 20 ng/mL and > 20 ng/mL). On Cox proportional analysis, age and vitamin D concentration were shown to be risk factors associated with mortality in patients with COVID-19 (age: HR = 1.036, 95% CI = 1.016-1.058, p < 0.001; vitamin D: HR [≤ 20 ng/mL and > 20 ng/mL] = 0.478, 95% CI = 0.237-0.966, p < 0.040).
Conclusion:
Age and vitamin D concentration were predictive factors for mortality in COVID-19-infected patients.
Palavras-chave : Vitamin D; COVID-19; Respiratory epithelium inflammatory response; Predictive factor.