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Revista de investigación clínica
versão On-line ISSN 2564-8896versão impressa ISSN 0034-8376
Resumo
XU, Rui et al. Association of Bone Mineral Density with Chronic Obstructive Pulmonary Disease in Postmenopausal Women. Rev. invest. clín. [online]. 2019, vol.71, n.3, pp.204-210. Epub 12-Abr-2021. ISSN 2564-8896. https://doi.org/10.24875/ric.19002935.
Background
Osteoporosis (OP) is common in patients with chronic obstructive pulmonary disease (COPD). The relationship between OP and COPD has been primarily studied in male patients, and few reports are available in postmenopausal women.
Objective
The purpose of this study was to investigate the association between bone mineral density (BMD) and COPD in postmenopausal women.
Methods
This cross-sectional study included 133 clinically stable female ex-smokers with confirmed COPD, and 31 age-matched ex-smoker female controls. We analyzed groups according to their airway obstruction category. BMD was measured on dual-energy X-ray absorptiometry images of the left femoral neck.
Results
Patients with COPD had lower T-scores and higher prevalence of osteopenia/OP than the control group. In the COPD group, the airway obstruction category was significantly associated with the T-score after adjustment for confounders. Multivariate logistic regression analysis showed COPD was an independent marker for increased risk of osteopenia/OP in postmenopausal women.
Conclusions
COPD and airway obstruction category were strongly related to BMD. Postmenopausal women with COPD, especially those with severe airway obstruction, had a higher prevalence rate and a higher risk of osteopenia and OP than female controls without COPD.
Palavras-chave : Osteoporosis; Obstructive pulmonary disease; Postmenopausal women.