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Revista de investigación clínica
versão On-line ISSN 2564-8896versão impressa ISSN 0034-8376
Resumo
JUAREZ-VAQUERA, Víctor H.; ROSETTI-SCIUTTO, Marcos F.; MORALES-RUIZ, Valeria e ADALID-PERALTA, Laura V.. Meta-analysis to Implement Alpha-Synuclein in Extracellular Vesicles as a Potential Biomarker for Parkinson's Disease. Rev. invest. clín. [online]. 2023, vol.75, n.4, pp.193-202. Epub 18-Set-2023. ISSN 2564-8896. https://doi.org/10.24875/ric.23000017.
Background:
In Parkinson's disease (PD), exosomes carry α-synuclein (α-syn), a fibrillar protein aggregates with potential value as a biomarker.
Objective:
Evidence on blood levels of exosomal α-syn in PD patients and controls was reviewed for their consistency.
Methods:
Thirty-six studies on exosomal α-syn concentrations in PD were identified in a systematic literature search and meta-analysis.
Results:
Both raw and ratio-adjusted blood exosomal α-syn levels were consistently higher in PD patients than in controls. The standardized mean difference (SMD) was 1.54 (0.18-2.90, CI95%, p < 0.01) and 1.53 (0.23-2.83, CI95%, p < 0.01), respectively.
Conclusion:
Our results suggest that exosomal α-syn concentrations could be a useful biomarker for PD.
Palavras-chave : Parkinson; Alpha-synuclein; Exosome; Biomarker; Blood.
