Resumo

SANCHEZ-ZAUCO, Norma Angélica; GIONO-CEREZO, Silvia  e  MALDONADO-BERNAL, Carmen. Toll-like receptors, pathogenesis and immune response to Helicobacter pylori. Salud pública Méx [online]. 2010, vol.52, n.5, pp.447-454. ISSN 0036-3634.

Helicobacter pylori colonize the gastric epithelial, most infected people are asymptomatic, 10 to 20% develop atrophic gastritis, peptic ulcer and less than 3% gastric cancer. These diseases are determined by the relationship between virulence factors of bacteria, host factors such as, genetic predisposition, and immune response. The innate immune response mainly represented by Toll-like receptors and Nod-like receptors that recognize their specific ligands, activate transcription factors as NF-kB, AP-1, CREB-1, inducing production of inflammatory cytokines such as IL -8, IL-12, IL-6, IL-1β, IL-18, TNF-α and IL-10. Chronic inflammation promotes gastric morphological changes, prevents apoptosis and allows angiogenesis generating neoplasic lesions and cancer. The aim of this review is to analyze the mechanisms proposed to date of the innate and adaptative immune response involved in H. pylori infection; remarking the mechanisms related in the elimination or persistence.

Palavras-chave : immunity, inate; adaptative immunity; Helicobacter pylori [pathogenicity].