Objective:

To estimate excess mortality from all causes in Mexico in 2020.

Materials and methods:

We constructed an endemic channel with deaths (2015-2018) establishing the epidemic threshold at the 90th percentile, comparing with death certificates counts to estimate excess mortality.

Results:

At week 53, there were 326 612 excess deaths (45.1%), with a maximum in week 28 (98.0%) and a minimum at week 41 (35.2%); after week 42, the increasing trend remained for the rest of the year. It was proportionally higher in men, mainly aged 45-64 years, however, in those aged 60 and over, the highest number of deaths occurred.

Conclusion:

In Mexico, excess mortality has been prolonged compared to other countries, with high interstate variability. This could be explained by socioeconomic conditions and the high prevalence of comorbidities in the Mexican population.