Resumo

CUADROS-MENDOZA, Carlos Augusto et al. The exposome influence in the first 1,000 days old and gastrointestinal health. Acta pediatr. Méx [online]. 2018, vol.39, n.3, pp.265-277. ISSN 2395-8235.  https://doi.org/10.18233/apm39no3pp265-2771611.

It is world widely accepted that a relatively small proportion of chronic disease can be explained by genetic factors alone. Although information about environmental exposure is important to comprehensively evaluate chronic diseases, this information is not sufficiently or accurately assessed by comparison with genomic factors. Human research on this topic has generally focused on single exposure health effect relationships. The “exposome” concept encompasses the totality of exposures from conception onward, complementing the genome. Developmental periods in early life may be particularly vulnerable to impacts of environmental exposures. The gastrointestinal exposome represents the integration of all xenobiotic components affecting the host health, disease progression and ultimately clinical outcomes during the lifespan. Therefore, a better understanding the interaction between microbiome and the gastrointestinal exposome would provide new insights into the clinical intervention, through regulation of the gut-associated immunological, metabolic, or neuroendocrine system. This review of the literature focuses on exposome, its theoretical construct, importance, characteristics and influence in the first 1000 days old and gastrointestinal health. It was revised 70 bibliography references, especially articles published in academic journals, related to this subject from the year 2000 to present.

Palavras-chave : Exposome; Early-life; Gastrointestinal exposome; Microbiota; Gastrointestinal immunity and inflammation; Xenobiotic.