Resumo

LEON-ORTIZ, AG; GUAMAN-CRESPO, JO; SANCHEZ-ZUNIGA, MJ  e  CARRILLO-ESPER, R. Granulomatosis with polyangiitis, Wegener granulomatosis. Med. interna Méx. [online]. 2017, vol.33, n.3, pp.421-426. ISSN 0186-4866.

Wegener's granulomatosis is a systemic necrotizing vasculitis that affects small and medium vessels, is associated with the expression of cytoplasmic ANCA antibodies. Characteristically disease causes airway injury and glomerulonephritis. Respiratory compromise is expressed as sinusitis, otic and nasal pathology, alveolar hemorrhage, being the most serious manifestation of lung involvement. Kidney damage is not indicative of severity, but it is of prognosis, so it is recommended to do a renal biopsy at the time of diagnosis of the disease. Treatment will depend on the severity of the clinical manifestation; it has a phase of remission induction and other of maintenance. In cases of massive alveolar hemorrhage or damage to any other target organ, plasma-pheresis should be considered, as it has proven be highly effective in terms of remission.

Palavras-chave : granulomatosis; Wegener; vasculitis.

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