Resumo

RUBIO-GUERRA, AF.. Cardiovascular safety of non-steroidal anti-inflammatory drugs. Med. interna Méx. [online]. 2017, vol.33, n.6, pp.809-812. ISSN 0186-4866.  https://doi.org/10.24245/mim.v33i6.1465.

Non-steroidal anti-inflammatory drugs are broad use drugs in the medical practice, their main adverse effects are gastrointestinal complications; however, in the last 10 years their cardiovascular safety has been questioned. The results from the Vioxx Gastrointestinal Outcomes Research (VIGOR) trial challenged the cardiovascular safety of Cyclooxygenase-2 (COX 2) inhibitors. In this review, the results of the Prospective Randomized Evaluation of Celecoxib Integrated Safety versus Ibuprofen or Naproxen (PRECISION) trial are analysed, as well as their impact on the latest indications for this family of drugs.

Palavras-chave : non-steroidal anti-inflammatory drugs; PRECISION trial; celecoxib; cardiovascular safety.

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