Resumo

AUDIFFRED JARAMILLO, Ricardo Ignacio; GARCIA COBIAN, Teresa Arcelia; GARCIA DE ALBA GARCIA, Javier Eduardo  e  RUBIO ARELLANO, Edy David. Association of MTHFR C677T polymorphism with symptomatic predominance in a sample of schizophrenic patients from Jalisco, Mexico. Acta univ [online]. 2016, vol.26, n.1, pp.56-64. ISSN 2007-9621.  https://doi.org/10.15174/au.2016.838.

Schizophrenia is a severe mental illness that has been recently associated with some genetic mutations as MTHFR C677T polymorphism. The objective was to evaluate the statistic association of MTHFR C677T polymorphism with symptomatic predominance in a sample of schizophrenic patients from Jalisco, Mexico. The study has a descriptive, retrospective, cross-sectional design, which analyzed a total of 49 patients classified by their symptomatic predominance with the Positive and Negative Syndrome Scale (PANSS) scale to determine their association with any polymorphism of MTHFR C677T polymorphism. The sample was in Hardy-Weinberg equilibrium. The allele frequency for T was 51% and for homozygous TT 31%. No statistic difference between genotypes and symptomatic predominance: CC/CT (p = 0.72), CC/TT (p = 0.84), CT/TT (p = 0.88). The homozygous T and positive symptoms were more frequent in women. In contrast, the heterozygous CT and negative symptoms had more prevalence in men. The thermolabile variant of MTHFR gene (homozygous T) in schizophrenic patients, is not related to present symptomatic predominance.

Palavras-chave : Schizophrenia; MTHFR C677T polymorphism; PANSS scale; Mexico.

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