Resumo

MORET, Marcelo A. et al. Beyond Phylogenetics: Darwinian Evolution of Actin. Rev. mex. ing. bioméd [online]. 2019, vol.40, n.1, e201801EE1. ISSN 2395-9126.  https://doi.org/10.17488/rmib.40.1.6.

Actin polymerizes to form cytoskeletons which stabilize and direct motion of cellular walls. It is one of the most stable proteins, having evolved little from algae and yeast, and very little from fish. Here we analyze actin evolution using modern theories of water-protein shaping interactions, and how these have evolved to optimize protein functions. We conclude that the failure of phylogenetic analysis to identify positive Darwinian evolution has been caused by 20th century technical limitations. These are overcome using 21st century thermodynamic scaling and modular averaging. The results for actin are especially striking, and reflect dual stable structures, globular and polymerized.

Palavras-chave : proteins; Darwinian evolution; actin.