OBJECTIVE:

To assess the effect of a combined therapy with myoino-sitol (MI) and D-chiro-inositol (DCI) in Polycystic Ovary Syndrome (PCOS) patients.

MATERIALS AND METHODS:

An experimental, prospective, longitudinal study. It includes patients with PCOS diagnostic (by Rotterdam criteria) that have not received any form of therapy or management for the syndrome. All patients received an oral daily administration of MI and DCI for 90 days. Clinic and metabolic profiles are assessed pre and postreatment.

RESULTS:

Sixty-one patients are included and we observed an improvement in Ferriman-Gallwey scale (6.06 ± 2.0 y 5.57 ± 1.1; p=0.003, pre-and postreatment, respectively); left ovary volume (7.76 ± 3.2 y 7.18 ± 2.3; p=0.005, pre and postreatment, respectively). Left ovary antral follicle count (10.65 ± 6.4 y 10.20 ± 5.7; p=0.029, pre and postreatment, respectively) and right ovary antral follicle count (12.11 ± 6.5 y 11.75 ± 6.1, p=0.048, pre and postreatment, respectively). There is also an improvement in HOMA (1.85 ± 1.0 y 1.67 ± 0.7, p=0.015, pre and postreatment, respectively) and LH/FSH ratio (1.13 ± 0.8 y 0.99 ± 0.6, p=0.018 pre and post treatment, respectively).

CONCLUSION:

We observed a positive effect with the combined administration of MI and DCI in clinic and metabolic profile of PCOS patients. Improvement in androgen profile, LH/FSH ratio and restoring menstrual cycles, may have a positive effect over the infertility caused by an anovulatory factor.