BACKGROUND:

paraneoplastic neurological syndromes are disorders associated with neoplasias, generally from autoantibodies produced by the tumor itself that cause crossed immunity with antigens in the central nervous system. A new neuropsychiatric disease was described recently in young women with ovarian teratoma that produce antibodies against the N-methyl-D-aspartate receptor that is part of the spectrum of limbic encephalitis.

CLINICAL CASE:

20 year old patient with a significant neuropsychiatric picture with a final diagnosis of limbic encephalitis from anti rNMDA antibodies secondary to ovarian teratoma, and total remission of the neurological picture after multimodal treatment.

CONCLUSION:

to our knowledge it is the first case of anti rNMDA limbic encephalitis due to ovarian teratoma reported with complete remission of the picture after multimodal treatment with surgery, immunosuppression and immunomodulation.