BACKGROUND:

Progesterone is a steroid hormone involved in ovulation, implantation, pregnancy and regulation of uterine function during the menstrual cycle and other organs such as the mammary gland. Because of its mechanism of action, progesterone is indicated in different gynecological and obstetric conditions: premenstrual syndrome, threatened abortion, preterm birth, dysfunctional uterine bleeding and mastalgia related to the menstrual cycle.

OBJECTIVE:

To evaluate the safety and efficacy of progesterone in patients with: premenstrual syndrome, threatened abortion, preterm birth, dysfunctional uterine bleeding, mastalgia and hormone therapy in menopause.

MATERIAL AND METHODS:

Systematic review of scientific evidence about different indications of progesterone.

RESULTS:

We found 92 articles from wich 41 were selected for review.

CONCLUSIONS:

The clinical evidence evaluated on different indications of progesterone demonstrates advantages in efficacy and safety in different regimens.

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