OBJECTIVE:

To determine the relation between uric acid and metabolic and anthropometric parameters and adipokines leptin and adiponectin in post-menopausal women.

MATERIALS AND METHODS:

A descriptive cross-sectional study was performed in post-menopausal women. Anthropometric measurements were taken by electric bioimpedance, and fasting venous blood samples were taken to determine glucose, total cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides by enzyme techniques, and levels of adiponectin, leptin and insulin were measured by radioimmunoassay. Insulin resistance was calculated using HOMA-IR. The variables were described with mean and standard deviation. Statistical analysis was performed by Pearson correlation test to evaluate the relation between uric acid and the study variables, and a multiple regression was performed to determine the parameters with greatest influence on uric acid.

RESULTS:

The study included 90 post-menopausal women aged 55 to 84 years. The average age of the participants was 63.7 years, and the average concentration of uric acid was 4.9 mg/dL. In bivariate analysis, anthropometric parameters, LDL-cholesterol, triglycerides and leptin showed positive association with uric acid, and HDL-cholesterol and adiponectin had a negative one. In multiple regression analysis, body fat associated with uric acid independent of body weight (beta=0.592, p=0.037).

CONCLUSIONS:

Uric acid relates with an adverse cardio-metabolic profile in post-menopausal women.

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