OBJECTIVE:

To evaluate the effect of myoinositol soft-gel capsules on HOMA index reduction, metabolic and hormonal control in patients with polycystic ovary syndrome versus metformin and gastrointestinal tolerability of both.

MATERIALS AND METHODS:

Prospective, open-label, non-randomized vs active reference controlled clinical study with parallel group design performed in the Human Reproductive Biology service of the High Specialty Medical Unit 23, IMSS, Monterrey NL, from August 2019 to October 2020, in patients with insulin resistance associated with polycystic ovary syndrome and infertility.

RESULTS:

83 patients were studied: 33 who received 600 mg myoinositol soft-gel capsules orally every 12 h and 50 who took 850 mg metformin every 12 h for 12 weeks. Seventy-five patients completed the study. The myoinositol-treated group had a reduction in HOMA index of 1.49 ± 1.05 (with delta value of change) versus the metformin-treated group of 0.42 ± 0.40 (with equal delta value of change). The difference between the two groups was statistically significant. Other metabolic and hormonal parameters also had favorable outcomes in both groups, but with a superior trend in the myoinositol group.

CONCLUSIONS:

The advantage of myoinositol treatment in reducing the HOMA index and other metabolic and hormonal parameters in patients with insulin resistance associated with polycystic ovary syndrome and infertility was demonstrated, with good gastrointestinal tolerability.

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