Resumo

ABOU-EL-WAFA, Ghada S. E.; SHAABAN, Khaled A.; EL-NAGGAR, Mohamed E. E.  e  SHAABAN, Mohamed. Bioactive constituents and biochemical composition of the egyptian brown alga Sargassum Subrepandum (Forsk). Rev. latinoam. quím [online]. 2011, vol.39, n.1-2, pp.62-74. ISSN 0370-5943.

During our search program for bioactive compounds from Egyptian marine sources, we isolated a spatane diterpene tetraol (1), fucosterol (2) and linoleic acid (3) from the brown alga Sargassum subrepandum (Forsk) C.Ag. In addition to those compounds, the four hydrocarbons were detected by using GC-MS named heptadecane, 2,6,10,14-tetramethyl-hexadecane, nonadecane and heneicosane. The chemical structure of 1 is assigned here definitely to first time by spectroscopic analyses including mass spectrometry (EI-MS, HR/EIMS), 1D and 2D NMR experiments. Phytochemical study of the unsaponified fraction of the algal extract and analysis by GC-MS confirmed the existence of nine compounds, among them 4,4,7a-trimethyl-5,6,7,7a-tetrahydrobenzofuran-2[4H]-one (6). In this article, we report as well the biochemical composition of Sargassum subrepandum (including ash, fibre, lipid, carbohydrate, total protein, and amino acids compositions) together with biological activities of its extract and the isolated compounds using diverse assays.

Palavras-chave : Brown alga; Sargassum subrepandum (Forsk); Spatane diterpene; GC-MS; Biochemical composition; Biological activity.