Resumo

ESPINOZA-RAMOS, Rogelio  e  VILLAFUERTE-ROBLES, Leopoldo. Effect of the mixing method on the sustained release profile of pelanserin from HPMC / citric acid matrix tablets. Rev. Soc. Quím. Méx [online]. 2003, vol.47, n.1, pp.81-87. ISSN 0583-7693.

Matrices obtained by wet granulation, containing variable citric acid quantities and employing the model: M_t / M_inf = k tn, showed greater release constants (k_av = 0.236) and exponent n values (n_av = 0.736) than those obtained by mixing in the dry (tumbling mixing), k_av = 0.185 and n_av = 0.606. This indicates a greater tendency to a relaxation/erosion release mechanism of wet granulation compared to dry mixing. The results are attributed to changes in the citric acid distribution.

Palavras-chave : Pelanserin; HPMC; Mixing method; Sustained release; Citric acid.

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