Resumo

CHACON-GARCIA, Luis; RODRIGUEZ, M. Elena  e  MARTINEZ, Roberto. Cytotoxic Evaluation of a Series of Bisalkanoic Anilides and Bisbenzoyl Diamines. Rev. Soc. Quím. Méx [online]. 2003, vol.47, n.2, pp.186-189. ISSN 0583-7693.

A series of bisalkanoic anilides and bisbenzoyl diamines were synthesized with the aim of elucidating the relationship between molecular structure and cytotoxic activity. Twenty-one derivatives were synthesized and tested on three tumoral cell lines. No apparent relationship was observed between electronic effects and cytotoxic activity, but it was found that compounds in which the 4'-phenyl substituent is fluoride or bromide gave the best inhibition of tumoral cell growth.

Palavras-chave : Diamides; alkanediamides; cytotoxic activity.