Resumo

URIBE FLORES, Jesús Daniel; HERNANDEZ JACOME, Mercedes; GUEVARA DONDE, Jaime  e  SEGURA, Xóchitl. Losartan versus Enalapril in the reduction of left ventricular hypertrophy secondary to systemic arterial hypertension. Arch. Cardiol. Méx. [online]. 2004, vol.74, n.3, pp.192-199. ISSN 1665-1731.

Objective: To compare losartan and enalapril on reduction of left ventricular hypertrophy. Material and methods: Longitudinal, prospective, comparative, controlled study, of patients with moderate systemic arterial hypertension and echocardiographically proven left ventricular hypertrophy, randomized for treatment during six months with losartan 100 mg daily or enalapril 20 mg daily. The reduction of left ventricular mass index, was evaluated by echocardiogram basal and to six months. Statistical analysis: Student's t, Spearman and Pearson correlation coefficients. Results: 85 patients finished the study (43 in the losartan group and 42 in the enalapril group). After six months of treatment, the blood pressure values and the left ventricular mass index decreased in losartan and enalapril (p= .0000001 y .00001 respectively), without significative difference in the intergrupal comparative. We found correlation between diastolic and media blood pressure reduction (but not for systolic) and the decrease in left ventricular mass index in both groups. Conclusions: Both drugs were equally effective for control systemic arterial hypertension and produced a significant reduction of left ventricular hypertrophy, with modification of geometrical pattern to short time.

Palavras-chave : Losartan; Enalapril; Left ventricular hypertrophy; Systemic arterial hypertension.

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