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Archivos de cardiología de México
versão On-line ISSN 1665-1731versão impressa ISSN 1405-9940
Resumo
RODRIGUEZ PEREZ, José Manuel; GALLARDO, Guillermo J e VARGAS ALARCON, Gilberto. Molecular bases of heart failure. Arch. Cardiol. Méx. [online]. 2006, vol.76, suppl.4, pp.10-17. ISSN 1665-1731.
Heart failure (HF) is a complex pathophysiologic state in which delivery of blood and nutrients is inadequate for tissue requirements. HF almost always arises in patients with previous cardiovascular disease such as acute myocardial infarction, atherosclerosis, cardiomyopathy, myocarditis, congenital malformations, or valvular disease. Recently, substantial progress has been made to understand the etiology, pathogenesis, and mechanisms of HF. Several interrelated mechanisms such as oxidative stress, signal transduction, abnormalities in intracellular calcium handling, mitochondrial dysfunction and inherited mutations have been proposed as the triggers of HF.
Palavras-chave : Etiology; Heart failure; Molecular mechanisms; Mutations; Pathogenesis.