Serviços Personalizados
Journal
Artigo
Indicadores
- Citado por SciELO
- Acessos
Links relacionados
- Similares em SciELO
Compartilhar
Boletín médico del Hospital Infantil de México
versão impressa ISSN 1665-1146
Resumo
SUMOZA-TOLEDO, Adriana; ESPINOZA-GABRIEL, Mario Iván e MONTIEL-CONDADO, Dvorak. Evaluation of the TRPM2 channel as a biomarker in breast cancer using public databases analysis. Bol. Med. Hosp. Infant. Mex. [online]. 2016, vol.73, n.6, pp.397-404. ISSN 1665-1146. https://doi.org/10.1016/j.bmhimx.2016.10.001.
Background:
Breast cancer is one of the most common malignancies affecting women. Recent investigations have revealed a major role of ion channels in cancer. The transient receptor potential melastatin-2 (TRPM2) is a plasma membrane and lysosomal channel with important roles in cell migration and cell death in immune cells and tumor cells.
Methods:
In this study, we investigated the prognostic value of TRPM2 channel in breast cancer, analyzing public databases compiled in Oncomine™ (Thermo Fisher, Ann Arbor, MI) and online Kaplan-Meier Plotter platforms.
Results:
The results revealed that TRPM2 mRNA overexpression is significant in situ and invasive breast carcinoma compared to normal breast tissue. Furthermore, multi-gene validation using Oncomine™ showed that this channel is coexpressed with proteins related to cellular migration, transformation, and apoptosis. On the other hand, Kaplan-Meier analysis exhibited that low expression of TRPM2 could be used to predict poor outcome in ER- and HER2+ breast carcinoma patients.
Conclusions:
TRPM2 is a promising biomarker for aggressiveness of breast cancer, and a potential target for the development of new therapies.
Palavras-chave : Breast cancer; TRPM2; Biomarker; Ion channel; Microarray.