Resumo

DIAZ, Alfonso et al. Hypoglucemic and antihyperlipidemic activity of TiO₂ nanostructured-conjugated Stevia rebaudiana bertoni in a model of diabetes mellitus in rats. Rev. mex. cienc. farm [online]. 2013, vol.44, n.4, pp.36-42. ISSN 1870-0195.

Stevia Rebaudina Bertoni (SrB) is a plant with properties hypoglycemic and antihyperlipidemic. SrB has become a lead candidate for the treatment of Diabetes Mellitus (DM). Importantly, nanostructures in general and titanium dioxide (TiO₂) in particular have become effective tools for drug delivery. This project evaluated antidiabetic effect of TiO₂ nanostructured-conjugated SrB (TiO₂-SrB) when given in animal model of DM. Male rats DM-phenotype was induced by alloxan (200 mg/kg, ip). The coadministration of TiO₂-SrB induced a significant decrease in the glucose concentration at 24 hours and 30 days. Likewise, the concentrations of insulin, glycosylated hemoglobin, cholesterol, and triglycerides showed a significant recovery to basal levels. These results suggest that the TiO₂-SrB has a potent activity and prolonged as hypoglycemic and antihyperlipidemic. TiO₂-SrB can be considered as an effective treatment option for DM.

Palavras-chave : Diabetes; Stevia rebaudiana; nanostructures; hypoglycemic; antihyperlipidemic.