Resumo

IDHAYADHULLA, Akbar; KUMAR, Radhakrishnan Surendra  e  NASSER, Abdul Jamal Abdul. Synthesis, Characterization and Antimicrobial Activity of New Pyrrole Derivatives. J. Mex. Chem. Soc [online]. 2011, vol.55, n.4, pp.218-223. ISSN 1870-249X.

Here we describe pyrrole derivatives with potent antibacterial and antifungal activity. A new series of pyrrole 3a-e derivatives were synthesized using standard amination reactions. All the compounds presented here were obtained with high yields and under easy experimental conditions. Synthesized compounds were characterized by IR, ¹H NMR, ¹³C NMR, mass spectra and mass spectral fragmentation. Synthesized compounds were screened against E. coli and S. aureus for antibacterial activity, as well as against A. niger and C. albicans for antifungal activity. We were able to obtain compounds with higher or equal potency to the reference compounds (Ciprofloxacin and Clotrimazole). Our data shows that a 4-hydroxyphenyl ring in our most potent compound seems to be responsible for antifungal activity against C. albicans. Incorporation of a 4-hydroxyphenyl ring as a pharmacophoric feature against C. albicans is a promising prospect.

Palavras-chave : Pyrrole derivative; antimicrobial activity; structure-activity relationship.

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