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Journal of the Mexican Chemical Society
versão impressa ISSN 1870-249X
J. Mex. Chem. Soc vol.55 no.4 Ciudad de México Out./Dez. 2011
Article
OnePot Regioselective Synthesis of 4Bromopyrazole Derivatives Under Solvent Free Conditions
Heshmatollah Alinezhad,* Mahmood Tajbakhsh, and Mahboobeh Zare
Faculty of Chemistry, Mazandaran University, Babolsar, Iran. heshmat@umz.ac.ir.
Received June 2, 2011.
Accepted September 2, 2011.
Abstract
An efficient protocol for the one pot regioselective synthesis of 4bromopyrazole derivatives from 1,3diketones, arylhydrazines and Nbromosaccharin, in the presence of silica gel supported sulfuric acid as heterogeneous catalyst, under solvent free conditions, is reported.
Key words: 4bromopyrazole, solvent free, Nbromosaccharin, 1,3diketone, arylhydrazine.
Resumen
En este trabajo se informa de un método nuevo y eficiente para la síntesis regioselectiva y en una sola etapa de derivados del 4bromopirazol, a partir de 1,3 dicetonas, arilhidracinas y Nbromosacarina empleando como catalizador ácido sulfúrico soportado en gel de sílice, en ausencia de disolvente.
Palabras clave: 4bromopirazol, libre de solventes, Nbromosacarina, 1,3dicetona, arilhidracina.
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