Resumo

INAM, Muhammad et al. Impact of L-Pyroglutamic Acid on the Solubility of Puerarin: Preparation, Solid-State Characterization and Physicochemical Evaluation of Puerarin- L-Pyroglutamic Acid Co-Crystal. J. Mex. Chem. Soc [online]. 2023, vol.67, n.2, pp.143-151.  Epub 23-Mar-2024. ISSN 1870-249X.  https://doi.org/10.29356/jmcs.v67i2.1916.

Drug solubility plays a significant role in the successful therapeutic formulation. The objective of this work is enhancing the water solubility of Puerarin. We successfully synthesized a novel crystalline phase co- crystal of Puerarin (PUE) with L-pyroglutamic acid (PG) via recrystallization method and characterized by various solid-state characterization techniques. PXRD pattern shows the crystallinity phase co-crystal. The DSC analysis of co-crystal shows change in the thermal behavior compared with a pure form of PUE and PG. The FT-IR analysis shows change in the functional group frequency due to H-bonding interaction between PUE and PG molecule. The solubility of Pure PUE and co-crystal investigated in Pure water, pH 6.8 phosphate buffer solution and pH 1.2 acidic medium. co-crystal reveals improved solubility when compared with pure form of PUE. The time- dependent in vitro dissolution rate of co-crystal was more significant compared to the pure commercial form of PUE, demonstrating that co-crystal could be used as a useful product for pharmaceutical formulation with enhance properties.

Palavras-chave : Oral solubility; co-crystal; co-former; physicochemical properties; puerarin; solubility; dissolution.