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Acta médica Grupo Ángeles
versão impressa ISSN 1870-7203
Resumo
JIMENEZ MIRABAL, José David et al. Neurophysiological and structural evaluation of the behavior of the visual pathway in patients with multiple sclerosis. Acta méd. Grupo Ángeles [online]. 2020, vol.18, n.3, pp.268-273. Epub 31-Maio-2022. ISSN 1870-7203. https://doi.org/10.35366/95404.
Clinical assessment of the visual pathway is an important aspect in patients with multiple sclerosis (MS), visual evoked potentials (VEP) are the most commonly used neurophysiological study when optic neuritis (ON) is suspected.
Objective:
To determine the correlation of these tools with the behavior of the disease in Mexican patients with MS.
Material and methods:
59 patients (118 eyes) with multiple sclerosis (MS) were included, who met the inclusion criteria: > 18 years, EM-RR phenotype with EDSS < 5.5, in treatment with some disease modifier. To all patients were performed; Complete neurological evaluation with EDSS, ophthalmological examination, conventional VEP, OCT, cerebral MRI with gadolinium.
Results:
The female sex was the most frequent 66.1%, 38 eyes had a history of ON (EM-ON). In VEPs, the P-100 wave with the longest latency was 177 msec. 50.85% had an average reduction of G-RNFL, 51.66% corresponding to the LE. Decreased values of G-RNFL were found at baseline OCT in patients with MS-ON (p < 0.0003).
Conclusion:
These results confirm the sensitivity of PEVs in patients with MS-ON and EM-NON, as well as the increase of this to detect damage in the visual pathway when using both studies.
Palavras-chave : Multiple sclerosis; visual evoked potentials; P-100 latency; optical coherence tomography; G-RNFL thickness.
