SciELO - Scientific Electronic Library Online

 
vol.2 número4Efecto del número de parto de la cerda, la caseta de parición, el tamaño de la camada y el peso al nacer en las principales causas de mortalidad en lechonesProducción de forraje y composición morfológica del pasto Mulato (Brachiaria híbrido 36061) sometido a diferentes regímenes de pastoreo índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Journal

Artigo

Indicadores

Links relacionados

  • Não possue artigos similaresSimilares em SciELO

Compartilhar


Revista mexicana de ciencias pecuarias

versão On-line ISSN 2448-6698versão impressa ISSN 2007-1124

Resumo

CONTRERAS CORNEJO, Humberto et al. Design and construction of a polypeptide with immunogenic potential from suppressor of hairless binding domain from Drosophila melanogaster hairless protein. Rev. mex. de cienc. pecuarias [online]. 2011, vol.2, n.4, pp.415-428. ISSN 2448-6698.

Signal transduction pathways regulate the functions of different types of cells that constitute a multicellular organism; with the final goal of to regulate of target genes. The Notch signaling pathway is mainly involved in early and late embryo development, and recently has been described its participation in the adult organism proper function. Hairless, a protein member of the Notch signaling pathway modulates negatively this signal transduction pathway. Despite efforts to detect Hairless in higher animals, it has not been able to identify a homolog protein. The identification of a Hairless homolog protein is essential for the understanding of the regulatory processes during embryo development and other pathological processes where Notch pathway is involved. The Hairless counterparts described in insects have at least three highly conserved domains, where the Suppressor of Hairless binding domain is the most conserved. Using analysis in silico and molecular biology techniques was identified and delimited a peptide with immunogenic potential from the Suppressor of Hairless binding domain from Drosophila melanogaster Hairless protein. This peptide was used as antigen to generate polyclonal antibodies in hens. Sera were tested against total protein extract from fruit fly embryos.

Palavras-chave : Embryo development; Notch; Hairless; Immunogenic peptides.

        · resumo em Espanhol     · texto em Espanhol

 

Creative Commons License Todo o conteúdo deste periódico, exceto onde está identificado, está licenciado sob uma Licença Creative Commons