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Cirugía y cirujanos
versão On-line ISSN 2444-054Xversão impressa ISSN 0009-7411
Resumo
JIMENEZ-LIZAOLA, Rebeca B.; FUENTES-OROZCO, Clotilde; PEREZ-NAVARRO, José V. e MORAN-GALAVIZ, Rubén E.. Procalcitonin and C-reactive protein as predictive biomarkers of anastomotic leak in colorrectal surgery. Cir. cir. [online]. 2022, vol.90, n.6, pp.775-780. Epub 09-Dez-2022. ISSN 2444-054X. https://doi.org/10.24875/ciru.21000529.
Background:
There has been recent interest in the seric levels of procalcitonin (PCT) and C reactive protein (PCR) as a marker of intraabdominal infection after a colorrectal surgery, however, the actual literature remains inconclusive.
Objective:
To test if C-Reactive Protein (PCR) and procalcitonin (PCT) as predictive factors of anastomotic leak after colorectal surgery.
Method:
Retrospective cohort, of patients with ileostomy or colostomy who had intestinal transit restitution by general surgeons in our center, from march 2018 to march 2020.
Results:
We registered 4 (36.4%) anastomotic leaks. We compared median PCR and PCT between group 1 (without anastomotic leak) and group 2 (with anastomotic leak). Median PCT3PO was 4.86 ng/ml in group 1 vs 13.7 ng/ml in group 2, and PCT5PO was 1.3071 ng/ml vs 6.74 ng/ml (DS: 5.04 vs. 11.53 and 0.779 vs. 10.44). Median PCR3PO and PCR5PO was 194.7 mg/l in group 1 vs 100.97 mg/l in group 2, and 159.8 mg/l vs 65.67 mg/l, (DS: 88.78 vs. 82.01 and 94.77 vs. 58.009).
Conclusions:
Persistent higher levels of seric PCR and PCT at 3rd and 5th postoperative day could be an anastomotic leackage. This biomarkers might be added as additional criteria of discharge.
Palavras-chave : Anastomotick leak; Procalcitonin; C-reactive protein; Positive predictive value.