Resumo

CLAUDIO-RIZO, Jesús A.; CANO SALAZAR, Lucia F.; FLORES-GUIA, Tirso E.  e  CABRERA-MUNGUIA, Denis A.. Nanostructured metal-organic frameworks (MOFs) applied to controlled drug delivery. Mundo nano [online]. 2021, vol.14, n.26, 00008.  Epub 03-Mar-2021. ISSN 2448-5691.  https://doi.org/10.22201/ceiich.24485691e.2021.26.69634.

Metal-organics frameworks are coordination polymers constituted of a metallic center and an organic ligand that can be designed using biocompatible metal ions (e.g. Fe+3, Zn+2, Mg+2, Ca+2 y Mo+6) and bioactive organic ligands yielding to the modulation of the structure and properties materials in the nano scale. The aim of this work is provide an outlook about the materials applied for drug delivery systems, emphasizing the advantages, advances and challenges in the controlled drug delivery using nanostructured MOFs, the delivery mechanism, degradability and antimicrobial activity is also presented.

Palavras-chave : MOFs; nanostructure; controlled drug delivery; biocompatibility.