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Medicina crítica (Colegio Mexicano de Medicina Crítica)
versão impressa ISSN 2448-8909
Resumo
MORAN GUEL, Elida; TAMARIZ BECERRA, Antonio; RUIZ CERECERES, Jaime Iván e CISNEROS CASTOLO, Martín. Correlation of leukocytosis and intracranial injury in patients with traumatic brain injury. Med. crít. (Col. Mex. Med. Crít.) [online]. 2018, vol.32, n.4, pp.208-216. Epub 30-Jun-2020. ISSN 2448-8909.
Diffuse microvascular damage is associated with loss of cerebral vascular self-regulation and loss of integrity of the blood-brain barrier. Traumatic brain injury is associated with an increase in serum levels of catecholamines. Catecholamines are responsible for neutrophil deposits. Catecholamines increase the leukocyte count by introducing the marginal cells into the circulating pool. The acute phase response is also characterized by leukocytosis on admission. Therefore, the white cell count is likely to serve as an additional indicator to the diagnosis and prognosis of TBI.
Material and methods:
Longitudinal prospective cohort study. Patients treated in the emergency room with TBI were included, blood test and imaging studies were collected.
Results:
Of the patients treated with subarachnoid hemorrhage (SAH), a mean of leukocytes on entry of 17,718 10^3/µl on admission and 13,970 10^3/µl on 24 hours of trauma, with p = 0.000 and 0.001. In patients with subdural hematoma, a mean number of leukocytes was found at 18,212 10^3/µl and 13,319 10^3/µl at 24 hours, with p = 0.000 and 0.003. For patients with hemorrhagic contusion, leukocytes were found on admission on average 13,225 10^3/µl and at 12,501 10^3/µl at 24 hours, a p = 0.091 and 0.027. In patients with epidural hematoma, a mean of 16,527 10^3/µl leukocytes was found on admission, at 24 hours 13,240 10^3/µl, with p = 0.000 and 0.019.
Palavras-chave : Traumatic brain injury; subdural hematoma; subarachnoid hemorrhage; epidural hematoma; hemorrhagic contusion; leukocytosis.
