Resumo

MONTANEZ-RIOS, Alondra et al. Toxicity evaluation of thermosensitive nanogels in an in vivo model. Rev. cienc. tecnol. [online]. 2022, vol.5, n.3, e236.  Epub 14-Ago-2023. ISSN 2594-1925.  https://doi.org/10.37636/recit.v5n3e236.

This study uses C. elegans to assess the toxicity of copolymeric nanogels (NG) of N-isopropylacrylamide (NIPAAm) and 2-(diethylamino)ethyl methacrylate (DEAEM), prepared by surfactant-free emulsion polymerization using polyethylene glycol monomethyl ether methacrylate (PEGMA) as a reactive stabilizer. Nematodes ingested fluorescein-labeled NG, as demonstrated by fluorescence microscopy. Two different initiators, cationic and anionic, were used to initiate the synthesis of the NG. The results indicate that both types of NG affect the size and reproducibility of nematodes. C. elegans is a potential multicellular model to evaluate the toxicity of sensitive NG, avoiding the use of mammals for evaluations.

Palavras-chave : Nanogels; C. elegans; NIPAAm; Toxicity.